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Academic Paper

Deep Learning

Akifumi Hagiwara, Yujiro Otsuka, Christina Andica, Shimpei Kato, Kazumasa Yokoyama, Masaaki Hori, Shohei Fujita, Koji Kamagata, Nobutaka Hattori, Shigeki Aoki, Differentiation between multiple sclerosis and neuromyelitis optica spectrum disorders by multiparametric quantitative MRI using convolutional neural network, Journal of Clinical Neuroscience  DOI: 10.1016/j.jocn.2021.02.018

Kazuhiro Suzuki, Yujiro Otsuka, Yukihiro Nomura, YukihiroNomura, Kanako K.Kumamaru, Ryohei Kuwatsuru, ShigekiAoki, Development and validation of a modified three-dimensional U-net deep-learning model for automated detection of lung nodules on chest CT images from the Lung Image Database Consortium and Japanese datasets. Academic Radiology   DOI: 10.1016/j.acra.2020.07.030

Kumamaru KK, Fujimoto S, Otsuka YKawasaki T, Kawaguchi Y, Kato E, Takamura K, Aoshima C, Kamo Y, Kogure Y, Inage H, Daida H, Aoki S, Diagnostic accuracy of 3D deep-learning-based fully automated estimation of patient-level minimum fractional flow reserve from coronary computed tomography angiography. Eur Heart J Cardiovasc Imaging 2020;21(4):437-445  DOI: 10.1093/ehjci/jez160

Shohei Fujita, Akifumi HagiwaraYujiro OtsukaHori Masaaki, Takei Naoyuki, Hwang Ken-Pin, Irie Ryusuke, Andica Christina, Kamagata Koji, Akashi Toshiaki, Kunishima Kumamaru Kanako, Suzuki Michimasa, Wada Akihiko, Abe Osamu, Aoki Shigeki, Deep Learning Approach for Generating MRA Images from 3D Quantitative Synthetic MRI without Additional Scans. Investigative Radiology 2020;55(4):249-256  DOI10.1097/RLI.0000000000000628

Ryusuke IrieYujiro Otsuka, Akifumi Hagiwara, Koji Kamagata, Kouhei Kamiya, Michimasa Suzuki, Akihiko Wada, Tomoko Maekawa, Shohei Fujita, Shimpei Kato, Madoka Nakajima, Masakazu Miyajima, Yumiko Motoi, Osamu Abe, Shigeki Aoki, A novel deep learning approach with 3D convolutional ladder network for differential diagnosis of idiopathic normal pressure hydrocephalus and Alzheimer’s disease. Magnetic Resonance in Medical Sciences 2020;Epub 2020 Jan 22.  DOI: 10.2463/mrms.mp.2019-0106

Alice Le Berre, Koji Kamagata Yujiro Otsuka Christina Andica, Taku Hatano, Laetitia Saccenti, Takashi Ogawa, Haruka Takeshige-Amano, Akihiko Wada, Michimasa Suzuki, Akifumi Hagiwara, Ryusuke Irie, Masaaki Hori, Genko Oyama, Yashushi Shimo, Atsushi Umemura, Nobutaka Hattori, Shigeki Aoki, Convolutional neural network-based segmentation can help in assessing the substantia nigra in neuromelanin MRI. Neuroradiology 2019;61(12):1387-1395. Epub 2019 Aug 10.  DOI: 10.1007/s00234-019-02279-w

A. Hagiwara, Y. Otsuka, M. Hori, Y. Tachibana, K. Yokoyama, S. Fujita, C. Andica, K. Kamagata, R. Irie, S. Koshino, T. Maekawa, L. Chougar, A. Wada, M.Y. Takemura, N. Hattori and S. Aoki, Improving the Quality of Synthetic FLAIR Images with Deep Learning Using a Conditional Generative Adversarial Network for Pixel-by-Pixel Image Translation. American Journal of Neuroradiology 2018  DOI: 10.3174/ajnr.A5927

Real World Data Analysis

Izumi Kawachi, Shuichi Okamoto, Mariko Sakamoto, Hiroyuki Ohta, Yusuke Nakamura, Kosuke Iwasaki, Manami Yoshida, Shinzo Hiroi, Mieko OginoRecent transition of medical cost and relapse rate of multiple sclerosis in Japan based on analysis of a health insurance claims database. BMC Neurology (2019) 19:324  DOI: 10.1186/s12883-019-1534-9

Mitsuru Ohishi, Takuo Yoshida, Akinori Oh, Shinzo Hiroi, Tomomi Takeshima, Yujiro OtsukaKosuke Iwasaki, Yukio Shimasaki, Analysis of antihypertensive treatment using real-world Japanese data-the retrospective study of antihypertensives for lowering blood pressure (REAL) study. Hypertens Res 2019 Jul 6;42(7):1057-1067. Epub 2019 Mar 6.  DOI: 10.1038/s41440-019-0238-2

 

Mieko Ogino, Shuichi Okamoto, Hiroyuki Ohta, Mariko Sakamoto, Yusuke Nakamura, Kosuke Iwasaki, Manami Yoshida, Shinzo Hiroi, Izumi Kawachi, Prevalence, treatments and medical cost of multiple sclerosis in Japan based on analysis of a health insurance claims database. Clinical and Experimental Neuroimmunology (2017)  DOI: 10.1111/cen3.12411.

 

Shinzo Hiroi Yukio Shimasaki Takashi Kikuchi Yujiro OtsukaKosuke Iwasaki, Mitsuru OhishiAnalysis of second- and third-line antihypertensive treatments after initial therapy with an angiotensin II receptor blocker using real-world Japanese data. Hypertens Res 2016 Dec 28;39(12):907-912. Epub 2016 Jul 28.  DOI: 10.1038/hr.2016.96

 

Mieko Ogino, Izumi Kawachi, Kazuyoshi Otake, Hiroyuki Ohta, Yujiro Otsuka, Kosuke Iwasaki, Shinzo Hiroi, Current treatment status and medical cost for multiple sclerosis based on analysis of a Japanese claims database. Clin Exp Neuroimmunol 2016 May 23;7(2):158-167. Epub 2016 Mar 23.  DOI: 10.1111/cen3.12299